| Summary: | 碩士 === 逢甲大學 === 纖維與複合材料學系 === 104 === Micelles have been frequently used as carriers for drug delivery. In general, micelles suffered from severe problems regarding their colloidal stability in human blood, which appreciably limits their clinical applicability.
In this context, crosslinked micelles consisting of biodegradable polyethylene glycol-b-polylactide were prepared to enhance the colloidal stability of resulting micelles. To introduce covalently bonded crosslinkages into micelles, polyethylene glycol-b-poly(allyl functional polylactide-co- polylactide) (PEG-b-poly(ALA-co-LA)), a biodegradable amphiphilic copolymer, have been synthesized via a rational synthetic route.
The chemical structures of PEG-b-poly(ALA-co-LA) were well analyzed through various analysis methods. Following the synthesis, the PEG-b-poly(ALA-co-LA)s a were changed from amphiphilic copolymers to non-crosslinked micelles (NCLMs). Sequentially, these NCLMs were crosslinked via UV-induced radical chain polymerization, resulting in the crosslinked micelles (CLMs).
In PBS buffer , CLMs were observed to have enhanced colloidal stability than NCLMs according to their change in particle size and particle uniformity. The in vitro drug release results indicated that CLMs released their loaded drugs in a slower and more sustained manner as compared with NCLMs.
Moreover CLMs displayed insignificant cytotoxicity in MES-SA cells. As a consequence, CLMs have been verified as a non-toxic and highly biocompatible material for the use of biodegradable carriers.
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