A non-invasive measurement of skin autofluorescence as a marker of advanced glycation end products accumulation in chronic renal disease patients

• Main Authors: Yi-Fan Lin, 林宜範
• Other Authors: Yen-Lin Chang
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/8atd3j

碩士 === 中原大學 === 生物醫學工程研究所 === 104 === The accumulation of advanced glycation end products (AGEs) is thought to play a role in the pathogenesis of chronic complications of diabetes mellitus (DM) and renal failure. Cardiovascular diseases are the predominant causes of death in patients with end-stage renal disease undergoing hemodialysis. Skin autofluorescence (Skin AF) measurement is a non-invasive method for assessing accumulation of tissue AGEs. The aim of this study is to establish the reference curve of Skin AF for the Taiwan population and use the clinical data to determine the factors affecting the AGEs accumulation in chronic renal disease patients. 50 healthy subjects and 92 hemodialysis patients with chronic renal disease were enrolled in this study. The AGE Reader was employed to measure Skin AF and all the blood routine examination were recorded. The resultant mean values of Skin AF in healthy subjects are 1.35 ± 0.07 AU in 20-29 years; 1.88 ± 0.22 AU in 30-39 years; 2.02 ± 0.27 AU in 40-49 years; 2.22 ± 0.31 AU in 50-59 years; 2.38 ± 0.37 AU in 60-69 years; 2.99 ± 0.65 AU in 70-79 years; 3.60 ± 0.96 AU in 80-89 years. It depicts that the age is an important factor affecting the Skin AF. In the same age group the yellow race has higher level of Skin AF than the Caucasian. It shows that the Skin AF measurement is affected by skin color. It also results show that glycation levels is the strongest factor affecting the accumulation of AGEs in the chronic renal disease subjects (include with DM and without DM groups), and then dialysis duration, albumin and triglyceride.