Ionically cross-linked polyelectrolytes in antimicrobial and adhesive applications

• Main Authors: Chia-Hsin Chiang, 蔣家欣
• Other Authors: Yung-Chang
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/11035011167659265739

碩士 === 中原大學 === 化學工程研究所 === 104 === The ability to kill bacteria is an important characteristic for biomaterials and medical devices. We report a multifunctional ionically cross-linked polyelectrolyte gel that possesses adhesive capabilities and antimicrobial. We synthesized poly((trimethylamino)ethyl methacrylate chloride(pTMAEMA))- co –sulfobetainemethacrylate(SBMA) (pTMA-co-pSBMA) copolymer to ionically cross-link with hexameta phosphate (PP). The gels form spontaneously when synthetic polycations, such as (pTMAEMA) are mixed with strongly bound multivalent anions like hexameta phosphate (PP). The special ion-pairing interactions in the gel give rise to a superglue like characteristic to almost all kinds of materials. For gel formation it is was found that when pTMA ratio is higher we can get the gel easier. Also when the water content is higher the gel becomes harder to disrupt by NaCl. On the other hand when pTMA ratio are smaller the gel were more environmental friendly showed by the disruption of the gel easily. The results from the viscosity of the gel showed that the gels’ viscosity can be restored to its initial state despite agitation by letting the gel rest for some time, this phenomena is also known as the thixotropic phenomenon. The antibacterial property of the gel was observerd when more pTMA was present in the gels. The ionic gel also exhibits cell viability at low concentration of the copolymer. Therefore we have successfully synthesized the copolymer forms a gel easily by mixing anions. This ionic gel have multifunctional properties including its adhesive strength, antibacterial, and environmental friendly .