| Summary: | 碩士 === 中山醫學大學 === 醫學研究所 === 104 === Background: Mycoplasma pneumoniae (MP) has been reported to be associated with initiation and persistence of asthma. It is unclear whether MP infection is associated with risk of developing asthma in Taiwanese children.
Objective: We investigated the association between MP infection and risk of asthma in children.
Methods: Pediatric patients newly diagnosed with MP between 2003 and 2011 were identified using National Health Insurance Research Database. Children with asthma before MP infection were excluded. Patients with MP infection (n= 3,321) were further analyzed by age (0-2, 3-5, and 6-18 years). We then frequency matched 13,284 patients without MP from the general population according to birth year, sex, and date of MP diagnosed. Subjects with MP were followed up until the end of 2011. Cox competing risk hazard model was used to calculate the hazard ratio (HR) of MP to estimate asthma risk in 3 age groups.
Results: Regardless of comorbidities, patients with MP infection had a higher risk of incident asthma than those without it in each age group. Compared with non-MP cohorts, the HRs of asthma were 1.44 (95%CI, 1.09-1.90), 2.19 (95%CI, 1.82-2.63), and 2.75 (95%CI, 1.88-4.03) for children with MP infection at the age of 0-2, 3-5, and 6-18 years, respectively.
Conclusions: MP was associated with increased risk of asthma in children, especially in children aged 6-18 years.
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