Pre-operative C-Reactive Protein as a Prognostic Factor after Surgical Resection of Hepatocellular Carcinoma

• Main Authors: Jian-Jhou Liao, 廖建洲
• Other Authors: Ming-Chih Chou
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/u3tcaj

碩士 === 中山醫學大學 === 醫學研究所 === 104 === Background: The study aimed to examine the prognostic value of pre-operative serum C-reactive protein(CRP) levels after surgical resection for hepatocellular carcinoma (HCC). Method: Six hundred forty-nine patients who underwent curative resection for HCC were reviewed retrospectively. Clinicopathologic variables were compared between patients with serum CRP levels < 0.3 mg/dL (n = 378 patients; the CRP-negative group) and patients with serum CRP levels >/= 0.3 mg/dL (n = 271 patients; the CRP-positive group). Univariate and multivariate analyses were conducted to identify factors that affected survival and disease recurrence. Results: The 1- and 3-year cumulative OS rates were 95.5% and 87.6% in group A and 81.2% and 70.5% in group B (p<0.00l). The corresponding RFS rates were 70.2% and 42.3% in group A and 51.5% and 32.3% in group B (p<0.00l). In multivariate analysis, the pre-operative CRP level was a significant prognostic factor linked to OS (p=0.001). Conclusion: Pre-operative CRP levels may be a useful prognostic factor after surgical resection for HCC.