The effect of SolanummuricatumAit extract on L-NAME-induced hypertension in mice

碩士 === 中山醫學大學 === 營養學研究所 === 104 === Cardiovascular disease is one of the main causes of death in many countries including Taiwan. Hypertension is the most common risk factor responsible for the progression of cardiovascular and cerebrovascular diseases. Solanum muricatum Ait (pepino) is a popular f...

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Main Authors: Han-Ju Lee, 李涵如
Other Authors: 徐成金
Format: Others
Language:zh-TW
Published: 2016
Online Access:http://ndltd.ncl.edu.tw/handle/e2rf89
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spelling ndltd-TW-104CSMU55130112019-05-15T23:09:50Z http://ndltd.ncl.edu.tw/handle/e2rf89 The effect of SolanummuricatumAit extract on L-NAME-induced hypertension in mice 香瓜茄水萃物對於以L-NAME誘發高血壓小鼠之影響 Han-Ju Lee 李涵如 碩士 中山醫學大學 營養學研究所 104 Cardiovascular disease is one of the main causes of death in many countries including Taiwan. Hypertension is the most common risk factor responsible for the progression of cardiovascular and cerebrovascular diseases. Solanum muricatum Ait (pepino) is a popular fruit in Penghu, Taiwan. Residents of Penghu consider that pepino could reduce blood pressure and control diabetes, but the scientific literature associated with anti-hypertensive effects of pepino was less. Thus, we used L-NAME to induce hypertension in ICR mice and investigated the protective effects of pepino aqueous extract. Mice were fed by 1% aqueous pepino extract for ten weeks. Blood and tissues were collected to analyze. Results showed that the intake of pepino extract significantly improved systolic blood pressure and diastolic blood pressure of mice. Furthermore, this extract significantly reduced the protein expression of ACE , aldosterone and arginine vasopressin concentration. The protein expression of ENaC and SGLT1 was also significantly decreased. In addition, this extract significantly increased glutathione content, catalase and glutathione peroxidase activities, as well as total antioxidant capacity in kidney. Pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6 and NF-κB protein expression were also lowered. These results suggested that pepino aqueous extract could attenuate hypertension, and decrease oxidative and inflammatory stress. 徐成金 2016 學位論文 ; thesis 65 zh-TW
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description 碩士 === 中山醫學大學 === 營養學研究所 === 104 === Cardiovascular disease is one of the main causes of death in many countries including Taiwan. Hypertension is the most common risk factor responsible for the progression of cardiovascular and cerebrovascular diseases. Solanum muricatum Ait (pepino) is a popular fruit in Penghu, Taiwan. Residents of Penghu consider that pepino could reduce blood pressure and control diabetes, but the scientific literature associated with anti-hypertensive effects of pepino was less. Thus, we used L-NAME to induce hypertension in ICR mice and investigated the protective effects of pepino aqueous extract. Mice were fed by 1% aqueous pepino extract for ten weeks. Blood and tissues were collected to analyze. Results showed that the intake of pepino extract significantly improved systolic blood pressure and diastolic blood pressure of mice. Furthermore, this extract significantly reduced the protein expression of ACE , aldosterone and arginine vasopressin concentration. The protein expression of ENaC and SGLT1 was also significantly decreased. In addition, this extract significantly increased glutathione content, catalase and glutathione peroxidase activities, as well as total antioxidant capacity in kidney. Pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6 and NF-κB protein expression were also lowered. These results suggested that pepino aqueous extract could attenuate hypertension, and decrease oxidative and inflammatory stress.
author2 徐成金
author_facet 徐成金
Han-Ju Lee
李涵如
author Han-Ju Lee
李涵如
spellingShingle Han-Ju Lee
李涵如
The effect of SolanummuricatumAit extract on L-NAME-induced hypertension in mice
author_sort Han-Ju Lee
title The effect of SolanummuricatumAit extract on L-NAME-induced hypertension in mice
title_short The effect of SolanummuricatumAit extract on L-NAME-induced hypertension in mice
title_full The effect of SolanummuricatumAit extract on L-NAME-induced hypertension in mice
title_fullStr The effect of SolanummuricatumAit extract on L-NAME-induced hypertension in mice
title_full_unstemmed The effect of SolanummuricatumAit extract on L-NAME-induced hypertension in mice
title_sort effect of solanummuricatumait extract on l-name-induced hypertension in mice
publishDate 2016
url http://ndltd.ncl.edu.tw/handle/e2rf89
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