| Summary: | 碩士 === 中山醫學大學 === 生化微生物免疫研究所 === 104 === Alcoholic liver disease caused by excessive alcohol consumption. When liver processed alcohol metabolism, it would produce highly toxic chemicals acetaldehyde. This chemical could hurt the liver cells and then lead to inflammation. In previous studies demonstrated mulberry leaves had been not only possess anti-oxidant promoting effects, but also regulates serum fasting glucose and lipid metabolism. However, the effect of mulberry leaf extract (MLE) on reducing acute alcoholic liver injury is unclear. In this study, we have examined MLE effect on alcohol induced acute liver injury in ICR mice. We assayed alcohol /acetaldehyde dehydrogenases(ADH and ALDH) activities. We found that MLE could reduce serum acetaldehyde concentration and promote ALDH and inhibit ADH activation and reduce liver inflammation. In addition, we also verified MLE could reduce apoptosis and reduce iNOS oxidative stress via caveolin-1 in HepG2 cells line. In summary, our results show that MLE effectively prevented and caused the regression of experimental acute liver injury through reducing acetaldehyde production. In the future, we could find the way to do more research about finding more effective compounds from mulberry leave so that we would have more solution about treating liver disease.
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