Enantioselective organocatalytic domino Michael-acetalization-Henry reaction for the synthesis of hexahydro-6H-benzo[c]chromenones and application
碩士 === 國立中正大學 === 化學暨生物化學研究所 === 104 === We use (E)-2-(2-nitrovinyl)phenol and aldehyde for the synthesis of hexahydro-6H-benzo[c]chromenones via enantioselective organocatalytic domino Michael-acetalization-Henry reaction, and construct four chiral centers in one step with excellent enantiosele...
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2015
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| Online Access: | http://ndltd.ncl.edu.tw/handle/pfz88t |
| Summary: | 碩士 === 國立中正大學 === 化學暨生物化學研究所 === 104 === We use (E)-2-(2-nitrovinyl)phenol and aldehyde for the synthesis of hexahydro-6H-benzo[c]chromenones via enantioselective organocatalytic domino Michael-acetalization-Henry reaction, and construct four chiral centers in one step with excellent enantioselectivity. Then the enantio-enrich hexahydro-6H-benzo[c]chromenones was transformed to the Aflatoxins analogs via a sequence of reduction and Nef reaction.
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