Atomistic Investigations into Mechanical Properties and Lock Mechanisms of Nano-liposome

• Main Authors: An-Bang Li, 李安邦
• Other Authors: Chung-Ming Tan
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/93931615529962641395

碩士 === 吳鳳科技大學 === 光機電暨材料研究所 === 103 === Liposomes are used for drug delivery due to their hydrophilicand and hydrophobic properties. Liposomes are a major component of phospholipids and may also contain mixed lipid chains with surfactant properties. In this study, the dipalmitoylphosphatidylcholine (DPPC) films are modeled by exploiting Dreiding potential to approximate liposomes layers. Our study investigates the variation in the mechanical properties of the DPPC during compression process at various temperatures. It is found that the mechanical strength of the DPPC decreases with the increasing temperature. In addition, the structure deformations and lock mechanism of DPPC in the micro-channel has also been studied. Overall, the results presented in this study reveal the potential for tuning the drug diffusion of liposome-deliveries through a careful control of their mechanical strengths.