| Summary: | 碩士 === 大同大學 === 材料工程學系(所) === 103 === In this study, the result demonstrated that iron doped hydroxyapatite nanocrystal with mesoporous structure was successfully prepared through one step route. mesoporous materials have gained enhanced interest with particular attention as drug storage and release hosts due to their higher surface area(54 m2/g) and unique textural properties. This material exhibits rod-like, crystalline structure, which is suitable for drug (Doxorubicin) release as drug carrier and prolong the release time(130 hr).Due to some tumor may overexpressing HER-2 genes, so it can immobilization HER-2 antibody onto MPmHAp surface to active targeting tumor cell and through receptor-mediated endocytosis, it can enhance cell uptake of HER2-MPmHAp(341.1 pg/cell). Finally, it can using chemohyperthermia that hyperthermia improves the antitumor effect of some chemotherapeutic agents.
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