Normal-tension glaucoma influence from damage in optic disc of different ethnicities and ages

• Main Authors: Shun-Chun Yang, 楊舜鈞
• Other Authors: 李宗翰
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/01749019048222340669

碩士 === 淡江大學 === 機械與機電工程學系碩士班 === 103 === In this study, the main body of research is focused on injuries to the optic disc of the eye ball due to normal-tension glaucoma. Because of developmental defects in the optic disc, the anterior intraocular pressure falls outside of the nominal range, producing visual field defects. The anterior IOP due to normal tension glaucoma is generally between the 10-20 mmHg. This study discusses the comprehensive design of an eye model, with analysis and reference to the simulation of the pathogenesis of normal-tension glaucoma. The resulting modeled values found for anterior pressure during normal-tension glaucoma were found to be in line with clinical pressure ranges. Utilizing stress distribution models, the maximum stress concentration was found to be in the rear of the sclera and the optic disc. In this study, the optic discs of Caucasians, Asians, and Africans are discussed, with the main difference between the three ethnicities lying in the different sizes of the optic disc of each respective ethnicity. This study found that, for the same anterior IOP, those of African descent will experience the highest stress concentrations in the optic disc of the three ethnicities, with those of Asian and Caucasian descent coming in second and third, respectively. This study also covers variations due to different ethnicities, different anterior IOPs, and different Young’s moduli. The results of this study can provide an important basis for future research.