Study of Polymethylmethacrylate Composite Bone Cement Adding with Tetracalcium Phosphate

• Main Authors: Han-Wen Liang, 梁瀚文
• Other Authors: Ren-Jei Chung
• Language: zh-TW
• Online Access: http://ndltd.ncl.edu.tw/handle/z72bv5

碩士 === 國立臺北科技大學 === 生化與生醫工程研究所 === 103 === Polymethylmethacrylate (PMMA) cement has been used in orthopedics for more than 70 years. The advantages of PMMA bone cement include high compressive strength, stickiness, deformable ability and rapid self-setting. But the heat produced during polymerization would hinder the recovery. In order to improve the properties, in this research we added tetracalcium phosphate (TTCP) into polymethylmethacrylate cement as TP cement. A serious of characterizations including thermal property study, compression strength and biocompatibility evaluation were carried out. According to the results, almost 50% polymerization heat was significantly reduced for the TP cement. The compressive strength was also enhanced with TTCP addition. TP1-10 and TP2-10 had better properties. As to thermal tests, TP1-40 and TP2-40 showed better results. In vitro studies including SBF immersion test and MTT assay were done. In SBF immersion test, TP cement would induce the precipitation of hydroxyapatite more easily than normal PMMA cement, and precipitation of hydroxyapatite was observed using SEM after 2 weeks immersion. The results of MTT assay showed that TP2-20 was much more biocompatible than blank.