| Summary: | 碩士 === 東海大學 === 化學工程與材料工程學系 === 103 === This study, we have investigated to synthesis and modification methods for the potential applications of SBA-15. Due to the morphology and dispersion of carrier particles are considered as the major effects to its biocompatibility and its applications for drug release, we have established an optimum method to synthesize well-dispersed spherical SBA-15 and improve the immobilization and release of protein by functionalizing the surface of SBA-15. Meanwhile, we have tried to use different surfactants for establishing new morphology of SBA-15. Furthermore, we added cross-linking agents or alternated the polarity of immobilization solution for better protein immobilization, as well as modified SBA-15 with gold nanoparticles for the adsorption of heavy metal, cobalt. At last, we have attempted to immobilize HRP on SBA-15 for the enzymatic polymerization conductive polymers, polyaniline(PANI) and poly(3,4-ethylene- dioxythiophene) (PEDOT).
According to the results, the pore diameter can be increased by adjusting the concentration of TMB, while maintaining the well-dispersed spherical SBA-15. By mixing two different surfactants, we can obtain the SBA-15 with its surface much thicker, and SBA-15 become more stable. Both adding cross-linking agents to the amine group of functionalized SBA-15 and adjusting the polarity with acetonitrile for the octyl group of functionalized SBA-15 are able to increase the percentage of immobilization protein. Attaching the gold nanoparticles on the SBA-15 could apparently increase the adsorption of the heavy metal of cobalt. For the polymerization of conductive polymers, we could synthesize PANI with HRP modified SBA-15 under the room temperature, but a heat procedure was required for the synthesis of PEDOT. On the other hand,we could improve our productivity by reducing the reaction time of forming free radical, and make our PEDOT chain much longer by adding PSS.
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