Effects of Fucoidan and Fucoxanthin Supplementation on Cardiac and Muscular Characteristics in Senescent Mice

• Main Authors: Chang, Po-Ming, 張博鳴
• Other Authors: Lin, Yen-Chang
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/82576929921944976424

碩士 === 中國文化大學 === 生物科技研究所 === 103 === Aging is accompanied by cardiac and muscular disorders and reduced abilities to produce normal functions that are considered to be the risk factors of falls and loss of functional independence. To date, studies have demonstrated that Fucoidan and Fucoxanthin are capable for improving collagen and epidermis formation and anticancer effects. However, if/how aging involves in reducing cardiac and skeletal muscular functions are still not very clear. In addition, whether Fucoidan as well as Fucoxanthin supplement is able to improve cardiac/skeletal muscular deficits caused by aging is still obscured. Our results indicated that: 1) Aging caused cardiac/skeletal muscular deficits (including cardiac arrhythmias; QT prolongation; skeletal muscular functional deficit etc.) accompanied with structural remodeling (including ventricular hypertrophy; cardiac fibroblast; vascular and skeletal muscular remodeling etc.) and cell apoptosis among cardiac and skeletal muscular systems in aged-mice model; 2) Fucoidan supplement alone improved cardiac/skeletal muscular deficits in mice aging model; 3) Fucoxanthin supplement alone ameliorated cardiac/skeletal muscular deficits in mice aging model; 4) Fucoidan combined with Fucoxanthin supplement had the synergistic effects on the improvement of cardiac/skeletal muscular deficits caused by aging. The results in this study suggested that Fucoidan alone and combined with Fucoxanthin supplement resulted in greater cardiac/skeletal muscular functional performances in aging mice than those without Fucoidan or/and with Fucoxanthin supplement. This application provided an insight into the effectiveness of Fucoidan intervention and had synergistic effects with Fucoxanthin supplement for reduced functional performances of cardiac/skeletal muscles in an older population.