Application of Thin Film Metallic Glasses Coated on Implantable Medical Devices: Effects on Reductions of Blood Cell Adhesion

• Main Authors: Yi-Ling Chen, 陳怡伶
• Other Authors: Jinn P. Chu
• Format: Others
• Language: en_US
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/h937s2

碩士 === 國立臺灣科技大學 === 材料科學與工程系 === 103 === Intravenous catheters are widely used in hospitals as the safe and essential pipelines to provide intravenous treatments, such as injections of medicine and nutritional supplements. Generally, the catheter is remained in a vein for some periods of time. It is easy to increase the opportunity of the phlebitis and sepsis due to the bacterial infection. Thin film metallic glass (TFMG) exhibits unique properties such as high strength, smooth surface as well as good wear- and corrosion-resistances due to its random-packing atomic structure. The biocompatibility and antibacterial property of TFMG can also be achieved, suggesting great potential for biomedical applications. In this study, Zr-based TFMG was deposited on catheter and medical-grade glasses by magnetron sputtering in order to decrease the chance for forming venous thrombosis. Surface roughness values of Ti-coated and bare glasses are similar, whereas the TFMG-coated one has relatively smooth surface. The Rq (root mean square) value of the bare glass is ~0.25 nm, which slightly decreases to 0.23 nm (a ~8% reduction) after coating with Ti and noticeably decreases to 0.19 nm (a ~27% reduction) after coating with TFMG. Based on the contact angle measurement results of various fluids on glass, the TFMG-coated glass exhibits more hydrophobic than that of bare one. The water contact angle of the bare sample surface is 60.1°, and this angle increases by ~63% after coating with TFMG (97.7°). There are less platelets aggregating on TFMG than on the bare glass in platelet adhesion test. According to experimental results, it is suggested that TFMG-coated catheters can be inserted into vessels for long periods of time with reduced numbers of the aggregation of blood platelets.