| Summary: | 碩士 === 國立臺灣科技大學 === 化學工程系 === 103 === Nano-architecture materials such as nanofibers are extensively studied due to their unique characteristics such as large surface area to volume ratio and flexibility in surface functionalization. In this study, a facile and versatile technique for the fabrication of TiO2 nanofibers by the combination of sol-gel and electrospinning techniques was proposed. The biocompatibility study of TiO2 fibers were also evaluated by culturing L-929 fibroblast cells.
Due to the physical properties of the used precursor, titanium (IV) butoxide (TBT), that was not able to be electrospun directly to generate TiO2 fibers. Poly(2-ethyl-2-oxazoline) was used as a template, followed by mixing with TBT, to proceed the sol-gel process through electrospinning for the preparation of Ti(OR)n-PEOXA fibers. The electrospinning parameters included the ratio between TBT and polymer (15:1, 10:1, 7.5:1 and 6:1), applied voltages (10, 15, 20 and 27 kV), and tip-to-collector distances (5, 10, and 15 cm) were investigated in relation with morphological characteristics and the mean diameter of the fibers. Subsequently, the remitted fibers were calcinated at 300 to 700 C in order to obtain pure TiO2 fibers (TiO2).
The as-prepared TiO2 fibers revealed average diameter ranging from 112 to 173 nm with random orientation. The results indicated that the calcination temperature significantly affected the fibers morphology, diameter size and crystalline phases. However, calcinated TiO2 fibers were fragile therefore PCL (polycarpolactone) was spin-coated on one side of TiO2 fibers in order to improve the mechanical strength. The (15:1)-Ti(OR)n-PEOXA, TiO2, and PCL-c-TiO2 fibers were characterized by fourier transformed infrared (FTIR), field emission scanning electron micrsocopy (FE-SEM), thermo-gravimetric analysis (TGA), Raman spectroscopy, and X-ray diffraction (XRD), BET surface area and interactions with mammalian cells.
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