Synthesis of graphene oxide-based magnetic nano-hybrids toward biomedical applications

碩士 === 國立臺灣科技大學 === 化學工程系 === 103 === Graphene Oxide has received tremendous attention in the field of materials science because of its extraordinary electrical, thermal, mechanical, and structural properties. Recently, great efforts have also been devoted to explore potential application of graphen...

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Bibliographic Details
Main Authors: Yu-Hsuan Hsu, 許宇萱
Other Authors: Toyoko Imae
Format: Others
Language:en_US
Published: 2015
Online Access:http://ndltd.ncl.edu.tw/handle/95928427200407657235
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Summary:碩士 === 國立臺灣科技大學 === 化學工程系 === 103 === Graphene Oxide has received tremendous attention in the field of materials science because of its extraordinary electrical, thermal, mechanical, and structural properties. Recently, great efforts have also been devoted to explore potential application of graphene oxide in biomedicine. Carbon coated iron nanoparticles are new kind of magnetic nanoparticles can be retained at tumor sites by a locally applied external magnetic field. In this study, the synthesis and characterization of cyclodextrin-immobilized graphene oxide (GO-CD), carbon coated iron nanoparticles (Fe@C) and Fe@C-bound GO-CD were successfully performed. Furthermore, the controlled loading of doxorubicin (DOX), an anti-cancer drug, onto GO, GO-CD, Fe@C, Fe@C-bound GO and Fe@C-bound GO-CD was investigated. It showed that the loading capacity of DOX on GO-CD was always higher than GO, since the inclusion of DOX in CD. Fe@C-bound GO-CD was most high because loading of DOX on Fe@C can occur via π-π stacking, hydrophobic and hydrogen bonding. The release profile shows strong pH dependence, especially when the interaction forces of the drug and nanomaterials are based on hydrogen bonds. And drug release behavior was invested at pH 5 and pH 7 due to the micro environments in the extracellular tissues of tumors and intracellular lysosomes and endosomes are acidic.