Preliminary study of applying the hemodynamic signal analysis in the breast cancer subjects

• Main Authors: Yen-Ting Liu, 劉彥廷
• Other Authors: Hsin Hsu
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/g44h3s

碩士 === 國立臺灣科技大學 === 醫學工程研究所 === 103 === Cancer has been top position of domestic top ten cause of death for thirty-two years. The occupied proportion is much more than cardiovascular diseases which is second position. Along with aging of population, unhealthy lifestyle and more, early detection of cancer has become a popular issue. Cancer can be attributed to unusual cell replication, and cancer cells had uninterrupted angiogenesis. The vessels of cancer cells are irregular and vessel characteristics are abnormal. This abnormal states will make human circulatory system uncharacteristic. Therefore we expect to early detect cancer by noninvasive measurement of human circulatory parameters. This preliminary study used blood-pressure waveform measurement system developed by ourselves and commercial laser doppler flowmetry to measure circulatory parameters of breast cancer patients. In addition, they will be compared to healthy females with matched age to study the patterns between cancer and human circulatory parameters. Experimental design defines right side of healthy females as control group. Cancer patients are defined as “A group” or “B group” by TNM staging system. We expect to find the differences between healthy females and cancer patients, as well as we want to know the influences caused by cancer in course of disease. According to experimental results, many parameter indicators we used in the study are significant. Blood-pressure waveform is relating with systemic circulation, we can evaluate systemic blood-supply states. Laser Doppler is relating with microcirculation, we can evaluate blood-supply states of local tissues. Combine both parameters can obtain more information of blood-supply states. At the present stage, we would like to verify that our measurement system is capable for analysis in cancer. In engineering, we can find many differences of indicators between healthy females and cancer patients, in medicine, we explained differences of indicators in physiology. We had some previous studies about PCOS, stroke, diabetes, and other diseases. We got foundation of studying diseases. Consequently, we expect this study to become first step of hemodynamic cancer detection, and construct accurate and convenient detection system.