| Summary: | 碩士 === 國立臺灣大學 === 電子工程學研究所 === 103 === In recent years, cardiovascular diseases have become the third place of top ten leading causes of death in Taiwan. There are many kinds of cardiovascular diseases, one of those is diabetes. The proportion of people suffering from diabetes is growing fast. Diabetes patients have to monitor their blood sugar level and control it carefully. However, the commercial glucose meter is not highly precise and can only measure temporary blood sugar level. Therefore, we want to develop a biosensor that has high sensitivity, high precision and can trace blood sugar level. To achieve his goal, we need to choose a reliable biomarker having a correlation with long-term blood sugar level and a good sensing mechanism. Silicon-nanowire field-effect-transistor(Si-NW FET) is a good choice. It has advantages such as high selectivity, high sensitivity, and can accomplish real-time detection.
In this research, we use commercial CMOS process to design Si-NW FET as biosensor, applying it to different biomarkers. First, we use it as a pH value sensor to verify sensing ability of our biosensor. After that, we use our biosensor to detect commercial purified antigen and identify the optimized measurement protocol of different biomarkers. Finally, we are able to distinguish different biomolecular concentration successfully.
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