| Summary: | 碩士 === 國立臺灣大學 === 公共衛生碩士學位學程 === 103 === Study title: Impact of individualized nutritional support in patients with colorectal cancer after surgery.
Objectives: To investigate the impact early individualized nutritional support on long-term physiological, quality of life (QoL), and nutritional outcomes in patients with colorectal cancer after surgery.
Methods: In this prospective randomized clinical trial that was carried out between
September 2014 to May 2015, patients who were diagnosed colorectal cancer and underwent surgery (n=84), were randomly arranged in a 1:1 ratio to receive either individualized nutritional counseling (interventional group, n=42), or usual care (control group, n=42). Nutritional intake (diet history), status (Patient-Generated Subjective Global Assessment), and QoL (EORTC QLQ - C30, QLQ - CR29) were evaluated at baseline and after one month and three months of surgery.
Results: At the one month and the three month followed ups, two groups were compared with nutritional status were significant improved in interventional group (p = 0.0352 and p < .0001). There were significant differences in EORTC QLQ - C30 scores and QLQ - CR29 scores between two groups in physical functioning (p= 0.0020), fatigue (p= 0.0002), financial difficulties (p= 0.0042), blood and mucus in stool (p< .0001), stool frequency (p= 0.0045) and hair loss (p= 0.0039) at the one month followed up. Besides, at the three months followed up, there were significant differences in EORTC QLQ - C30 scores and QLQ - CR29 scores between two groups in physical functioning (p= 0.0085), role functioning (p= 0.0043), cognitive functioning (p= 0.0062), fatigue (p= 0.0426), dyspnea (p= 0.0012), diarrhea (p= 0.0121), financial difficulties (p= 0.0331), weight (p< .0001), blood and mucus in stool (p< .0001), dysuria (p= 0.0358), abdominal pain (p= 0.0213) and dry mouth (p= 0.0002).
Conclusions: Early, timely and continuous individualized nutritional intervention was the key to the improvement of nutritional outcomes and quality of life to the patients with colorectal cancer after surgery.
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