| Summary: | 碩士 === 國立臺東大學 === 生命科學系碩士班 === 103 ===
The chronic liver injury can develop to liver fibrosis, because of the wound-healing in liver which is the process of excessively generated and accumulated extracellular matrix (ECM). The primary active compound of Cordyceps militaris is cordycepin, which has been reported to inhibit the activity of the hepatic stellate cells (HSCs) in TAA-induced liver fibrosis in rats. Cordycepin has the potential to decrease the accumulation of collagen fibrils in liver. Moreover, deep ocean water (DOW) can enhance the functional effect of by increasing the functional metabolites production in red mold dioscorea and Antrodia camphorate fermented product. However the effect of DOW on the anti-fibrosis effect of C. militaris-fermented product is still unknown, in current. In this study, first, the effect of DOW and its major ions on the production of cordycepin and adenosine were investigated. Second, C. militaris-fermented oats cultured in DOW was further investigated the functional effect against TAA-induced liver fibrosis in mice. We also investigated whether DOW can increase the effect of C. militaris-fermented oats on anti-liver fibrosis. Based on the results, DOW was more effective than UPW on increasing the production of adenosine and biomass in the submerged culture (p<0.05), but not
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