Synthesis of Benzothiazine and Thiochroman Derivatives

• Main Authors: Chang, Wei-Hsiang, 張韋翔
• Other Authors: Yao, Ching-Fa
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/33112473435032408615

碩士 === 國立臺灣師範大學 === 化學系 === 103 === The contents of this dissertation is divided into two parts summarizing the results based on the experimental works performed during the course of study. The first part is about the syntheses potential bioactive compounds such as benzothiazine derivatives from (2-formylphenyl) ethanethioate and dimer benzothiazine through a nucleophilic substitution reaction. In the second part, we developed an efficient method for the synthesis of thiochroman derivatives via DMAP catalyzed one pot reaction of (2-formylphenyl) ethanethioate and nitrostyrene derivatives in acetone at room temperature. The procedure is simple and mild condition to obtain the highly substituted thiochroman derivatives.