The Study on Asymmetric Tandem Michael/Mannich Reaction of Diethylzinc to trans-chalcone by Camphor Derived Chiral β-Amino Alcohol

The Study on Asymmetric Tandem Michael/Mannich Reaction of Diethylzinc to trans-chalcone by Camphor Derived Chiral β-Amino Alcohol

碩士 === 國立清華大學 === 化學系 === 103 === The thesis dealt with the application of camphor-derived chiral ß-amino alcohol in catalytic asymmetric tandem Michael/Mannich reaction of diethylzinc to trans-chalcone. Utilizing the complex of (+)-MINBOL 6 (12.5 mol%) and Ni(acac)2 (0.5 mol%) catalyzed the enantio...

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Main Authors: Chen, An Jyun, 陳安君
Other Authors: Uang, Biing Jiun
Format: Others
Language:zh-TW
Published: 2015
Online Access:http://ndltd.ncl.edu.tw/handle/9qj747
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spelling ndltd-TW-103NTHU50651212019-05-15T22:18:04Z http://ndltd.ncl.edu.tw/handle/9qj747 The Study on Asymmetric Tandem Michael/Mannich Reaction of Diethylzinc to trans-chalcone by Camphor Derived Chiral β-Amino Alcohol 樟腦衍生之掌性β-胺基醇在催化二乙基鋅試劑對反式-查耳酮進行不對稱麥可/曼尼希串聯反應之研究 Chen, An Jyun 陳安君 碩士 國立清華大學 化學系 103 The thesis dealt with the application of camphor-derived chiral ß-amino alcohol in catalytic asymmetric tandem Michael/Mannich reaction of diethylzinc to trans-chalcone. Utilizing the complex of (+)-MINBOL 6 (12.5 mol%) and Ni(acac)2 (0.5 mol%) catalyzed the enantioselective conjugate 1,4-addition of diethylzinc to trans-chalcone 12 afforded chiral zinc enolate 13. The chiral zinc enolate 13 was further reacted with imine 14a-k, which furnished Major products ß-amino ketone 4a-k (1S,2R,3S) with high enantioselectivity and good yield. Uang, Biing Jiun 汪炳鈞 2015 學位論文 ; thesis 122 zh-TW
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language zh-TW
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description 碩士 === 國立清華大學 === 化學系 === 103 === The thesis dealt with the application of camphor-derived chiral ß-amino alcohol in catalytic asymmetric tandem Michael/Mannich reaction of diethylzinc to trans-chalcone. Utilizing the complex of (+)-MINBOL 6 (12.5 mol%) and Ni(acac)2 (0.5 mol%) catalyzed the enantioselective conjugate 1,4-addition of diethylzinc to trans-chalcone 12 afforded chiral zinc enolate 13. The chiral zinc enolate 13 was further reacted with imine 14a-k, which furnished Major products ß-amino ketone 4a-k (1S,2R,3S) with high enantioselectivity and good yield.
author2 Uang, Biing Jiun
author_facet Uang, Biing Jiun
Chen, An Jyun
陳安君
author Chen, An Jyun
陳安君
spellingShingle Chen, An Jyun
陳安君
The Study on Asymmetric Tandem Michael/Mannich Reaction of Diethylzinc to trans-chalcone by Camphor Derived Chiral β-Amino Alcohol
author_sort Chen, An Jyun
title The Study on Asymmetric Tandem Michael/Mannich Reaction of Diethylzinc to trans-chalcone by Camphor Derived Chiral β-Amino Alcohol
title_short The Study on Asymmetric Tandem Michael/Mannich Reaction of Diethylzinc to trans-chalcone by Camphor Derived Chiral β-Amino Alcohol
title_full The Study on Asymmetric Tandem Michael/Mannich Reaction of Diethylzinc to trans-chalcone by Camphor Derived Chiral β-Amino Alcohol
title_fullStr The Study on Asymmetric Tandem Michael/Mannich Reaction of Diethylzinc to trans-chalcone by Camphor Derived Chiral β-Amino Alcohol
title_full_unstemmed The Study on Asymmetric Tandem Michael/Mannich Reaction of Diethylzinc to trans-chalcone by Camphor Derived Chiral β-Amino Alcohol
title_sort study on asymmetric tandem michael/mannich reaction of diethylzinc to trans-chalcone by camphor derived chiral β-amino alcohol
publishDate 2015
url http://ndltd.ncl.edu.tw/handle/9qj747
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