The Study on Asymmetric Tandem Michael/Mannich Reaction of Diethylzinc to trans-chalcone by Camphor Derived Chiral β-Amino Alcohol
碩士 === 國立清華大學 === 化學系 === 103 === The thesis dealt with the application of camphor-derived chiral ß-amino alcohol in catalytic asymmetric tandem Michael/Mannich reaction of diethylzinc to trans-chalcone. Utilizing the complex of (+)-MINBOL 6 (12.5 mol%) and Ni(acac)2 (0.5 mol%) catalyzed the enantio...
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| Other Authors: | |
| Format: | Others |
| Language: | zh-TW |
| Published: |
2015
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| Online Access: | http://ndltd.ncl.edu.tw/handle/9qj747 |
| Summary: | 碩士 === 國立清華大學 === 化學系 === 103 === The thesis dealt with the application of camphor-derived chiral ß-amino alcohol in catalytic asymmetric tandem Michael/Mannich reaction of diethylzinc to trans-chalcone. Utilizing the complex of (+)-MINBOL 6 (12.5 mol%) and Ni(acac)2 (0.5 mol%) catalyzed the enantioselective conjugate 1,4-addition of diethylzinc to trans-chalcone 12 afforded chiral zinc enolate 13. The chiral zinc enolate 13 was further reacted with imine 14a-k, which furnished Major products ß-amino ketone 4a-k (1S,2R,3S) with high enantioselectivity and good yield.
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