The association of Hepatitis B viral infection with the occurrence of cancers: A nationwide population-based cohort study

• Main Authors: Kai-yang Tsai, 蔡凱仰
• Other Authors: John Y. Chiang
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/23c3v4

碩士 === 國立中山大學 === 資訊工程學系研究所 === 103 === Liver cancer, mostly arising from hepatitis type A, B, C, D, and E, constitutes about 10% of total death in Taiwan. Among them, hepatitis B and C are regarded as the main culprits leading to liver cancer. The subsequent development after infecting hepatitis B or C has drawn scholars’ attention. Studies that analyze the relation between hepatitis B viral (HBV) and cancers flourish in academic field [1-10]. HBV is the risk factor for Hepatocellular Carcinoma (HCC) and accounts for at least 50% cases of HCC [1-3]. Recently the correlation between hepatitis viral infection and the occurrence of pancreatic cancer was also studied. Patients with HBV will have an increased risk of infecting pancreatic cancer according to studies conducted by China [4,5]. However, no significant relation was found in a reported by Taiwanese scholars [10]. The follow-up researches exploring the relevance of HBV infection to lymphoma were performed in many different countries. Italian scholar reported patients with B cell lymphoma have higher viral infection rate of hepatitis C [6]. On the other hand, researches performed in France, Germany and US revealed that such a relationship does not exist [6-9]. This indicates that the relation between hepatitis and cancer occurrence might be pending on factors relating to region or species. Even though the correlation between the infection of HBV and liver cancer was confirmed, yet relatively few researches targeting on the relation of HBV and the incidence of cancers other than liver cancer were reported. This study aims at evaluating the effect of HBV infection on cancers in Taiwan by analyzing data retrieved from National Health Insurance Research Database (NHIRD) from January 1996 to December 2010. A nationwide HBV cohort prospective study to investigate whether HBV increases the risks of cancers and cancers incidence in Taiwan. With the information provided by this research, the treatment and prognosis following can be properly planned and predicted.