Urinary 1-Hydroxypryene as a Biomarker of Exposure and Respiratory Health Effect in Schoolchildren

• Main Authors: Ke, Kai-Wei, 柯凱瑋
• Other Authors: Lai, Ching-Huang
• Format: Others
• Language: zh-TW
• Published: 2016
• Online Access: http://ndltd.ncl.edu.tw/handle/85393375505207216943

碩士 === 國防醫學院 === 公共衛生學研究所 === 104 === 　　Studies showed both PM2.5 concentration and composition of PM2.5 are associated with health effect. Since the major source of fine particulates come from combustion, studies have found a high correlation between PM2.5 and PAHs. Although epidemiological studies indicate PAHs and health effects related to the respiratory health effects, currently few studies investigate this issue in Taiwan. Previous studies have shown that metabolite of pyrene could be used as a biomarker of exposure to PM2.5. The purpose of this study was to identify the relationship between 1-OHP concentration and respiratory health effects in children. 　　The study was conducted as longitudinal design. We recruited 149 children from 2 elematary schools who live closed to industry area during the period January 2014 to January 2015. Data collection time frame was divided into four different sampling time points: summer Monday, summer Friday, winter Monday, winter Friday. Environmental PM2.5 sampling was conduct at first day. Biomarkers collected at second day which including: analyzing urine 1-OHP concentrations, lung function (PEF%, FEV1%) and airwary inflammation(FeNO). Statistical inference using Generalized linear model and Generalized estimating equation. 　　After controlling for possible influencing factors, overall 1-OHP concentrations for each additional unit (μg/g creatinine), PEF% average decline 3.16%, FEV1% average decline 1.20%, Log FeNO average decline 0.06 ppb. Among stratification season, in summer, 1-OHP concentrations for each additional unit (μg/g creatinine), PEF% average decline 2.42%, FEV1% average decline 1.62%. 　　This study found that, urine 1-OHP concentration have related to decline in lung function in schoolchildren, the change of seasons can lead to different relationships 1-OHP concentration and respiratory health effects. Is FeNO indicators apply to industry pollution sources, it would need further study.