| Summary: | 碩士 === 國立彰化師範大學 === 生物技術研究所 === 103 === The n-3 PUFA is important for human health, but can not be synthesised these
essential fatty acid in human body. It’s well known that n-3 fatty acids in
dietary fish oil are reported to have anti-inflammatory and injury effects in
humans, but the biochemical basis and the molecular mechanism for these
beneficial health effects is still not well understood. In our results,
Streptococcus iniae can alter the host immune response through toll-like
receptors (TLRs), and then promote the downstream target, Myd88 to induce
the expression of inflammatory related genes, and cause high mortality. By
comparison, the surrvival rate of transgene Δ5 and Δ6 desaturase zebrafish is
higher than wild type 1.33 folds. By the way, we try to use PD1 as a novel
inhibitor for NNV replication. The survival rate of PD1 treated GF1 was similar
to the control. ROS level significantly when comparing to the control cells. The
PD1 treated cells also decreased the cytopathic effect(CPE) at 42 hpi, but the
results is not so clear. We also machinery, and to understand the role of ROS
during NNV infection.
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