| Summary: | 碩士 === 國立中央大學 === 化學工程與材料工程學系 === 103 === A practical and convenient Co-catalyzed alkylation method targeting on the facile introduction of various alkyl chains into organic-electronically significant heteroaryls including thiophenes, furans, selenophenes, and pyrroles is reported. Under well-optimized reaction conditions, a wide range of alkylated heteroaryls are efficiently prepared in moderate to good isolated yields. Notably, 2- or 3-alkylthiophenes, as playing a decisive role in polymer chemistry and organic materials, are step-economically synthesized for the first time by present reductive-coupling methodology using inexpensive cobalt salts as catalyst. This straightforward synthetic method avoids the preparation of moisture-unstable organometallic reagents (RMgX or RZnX) and the use of precious catalysts ([Pd] or [Ni]) required in conventional alkylation protocols.
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