Fat-infiltrating B cells recognize mouse serum albumin and lipids in a diet-induced obese mouse model

• Main Authors: Cheng, Yu-Che, 鄭宇哲
• Other Authors: Tzou, Shey Cherng
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/2hrb98

碩士 === 國立交通大學 === 分子醫學與生物工程研究所 === 103 === Obesity is affecting the world and increasing dramatically. According to world health organization (WHO), in the world, 1.4 billion people are overweight and 0.5 billion are obese in 2008. Obesity is not only a global issue but also the major risk factor associated with metabolic syndrome which includes insulin resistance, glucose intolerance and diabetes, hepatic steatosis and hyperlipidemia. Obesity is manifested by low-grade adipose tissue inflammation that can cause systemic insulin resistance, although the mechanism is incompletely understood. The research about insulin resistance has been starting since 1993 and showing that obesity is associate with low-grade adipose tissue inflammation and TNF-α leads to insulin resistance. In 2003, study show that macrophages infiltrate to adipose tissue and cause inflammation and insulin resistance. Recently research show that adaptive immune cells infiltrate to adipose tissue and cause inflammation and insulin resistance. Obesity is not only metabolic problem but also immune-related disease which is linked to adipose tissue inflammation.