Organic pi-Conjugated Self-assembled Nanomaterials in the Applications of Bioimaging

• Main Authors: Liu, Yu-Hao, 劉育豪
• Other Authors: Lin, Hsin-Chieh
• Format: Others
• Language: zh-TW
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/7edrrg

碩士 === 國立交通大學 === 材料科學與工程學系奈米科技碩博士班 === 103 === In this study, the pi conjugated systems are modified by attaching to peptide sequence to gain some functionality or improvement. This thesis has two different parts. In the first part, we study the rheological properties of peptide hydrogels. Incorporation of a 1, 4, 5, 8-Napthalene tetracarboxylic diimide (NDI) and a dipeptide in the imide position, we found the composition of the peptides can determine the strength and gelation of this type of hydrogels. The four compounds are presented in the study (C8NDI-FF, C8NDI-FG, C8NDI-GF and C8NDI-GG) which forms stable hydrogel in acidic pH conditions. And with the increasing of the number of phenylalanine (Phe), the intermolecular  interactions can be enhanced. When considering the gelators of C8NDI-FF and C8NDI-FG, these hydrogelators can form hydrogels in the physiological environment. These results prove that the presence of the building block of C8NDI-F is an efficient way to construct the supramolecular system. In the second part, we study the properties of aggregation-induced emission (AIE) of the chromophores. The different size of cycloalkanes is used as electron-donating group to modify the 1, 8-naphthalimide (5RNI, 6RNI, 7RNI and 8RNI). Importantly, the 6RNI series exhibit AIE properties. We further extend this study to dipeptides where the combination of 6RNI and phenylalanine (Phe) or Tyrosine (Tyr) is conducted. The difference of hydrophobicity between these two amino acids can alter the properties of AIE. Through this study, we found a simple strategy to fabricate the one-dimensional (1-D) nano- and micro-structures in relatively large scale.