Synthesis and Characterization of Magnetically Targeted Cisplatin-loaded Carriers for Lung Cancer Therapy

• Main Authors: Tseng, Yi-Hsuan, 曾苡瑄
• Other Authors: Chen, San Yuan
• Format: Others
• Language: en_US
• Published: 2014
• Online Access: http://ndltd.ncl.edu.tw/handle/87796j

碩士 === 國立交通大學 === 材料科學與工程學系奈米科技碩博士班 === 103 === Cisplatin (CDDP) is one of the most potent chemotherapy agents, displaying significant clinical activity against a variety of solid tumors [1, 2]. However, a major clinical limitation of this drug is its side effects in normal tissues, prominently toxicity in the kidneys [3] and nonspecific biodistribution [4, 5]. The primary aim of this study is to develop a special delivery system to improve the aforementioned shortcoming. Here, we designed a novel nanocarrier for tumor therapy, which composed of polyvinyl alcohol (PVA), superparamagnetic iron oxide (SPIO) nanoparticles and polyacrylic acid (PAA), which electrostatic interact with CDDP[6]. Both of CDDP and PAA were encapsulated into the inner core by the simple double emulsion method. Blood biochemical analysis and histopathological studies revealed that CDDP-PAA-NC significantly reduced nephrotoxicity. Compared to free CDDP, prolonged blood circulation time and improved biodistribution were observed of CDDP-PAA-NC delivery in vivo. Furthermore, with an external magnet, CDDP-PAA-NC tended to show greater antitumor activity in A549 tumor bearing mice without body weight loss compared to that of CDDP.