Time-resolved diffuse optical tomography :development and clinical application

• Main Authors: Ciou, Chen-Wun, 邱宸聞
• Other Authors: Sun, Chia-Wei
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/tmyx3g

碩士 === 國立交通大學 === 光電工程研究所 === 103 === The advent of aging society is coming, the demand of medical resources is rising. In the medical environment in Taiwan, doctors of major diseases is less and less. So we hope to develop a near-infrared time-resolved diffuse optical system to assist doctors in the diagnosis of diseases. We present the experimental results of in-vivo oxygenation dynamic monitoring based on a time-resolved diffuse optical imaging (TRDOI) system. The TRDOI was performed with picosecond diode lasers (dual-wavelength near-infrared source) and a fast-gated single-photon avalanche diode (SPAD) that coupled to a time-correlated single-photon counting electronics. We applied the instrument in two parts of clinical. There are hemodynamic with vessel occlusion and diagnosis of breast cancer. We investigated the changes of absorption and reduced scattering coefficients in venous and arterial occlusion of arm from the mean time of flight and the variance of the measured distribution of times of flight (DTOF). Our result indicates the differences of change of optical properties with venous and arterial occlusion. The image breast cancer, our instruments is indeed to diagnose tumor location, and the measurement time compared to other medical diagnostic tool is quite fast. In the future, we will improve the accuracy of this system, I believe that our system would be useful in breast cancer diagnosis.