Mental Function and Attentional Function in Patients with Brain Metastasis Treated with Whole-Brain Radiation Therapy

• Main Authors: Hsiao-WenWang, 王筱雯
• Other Authors: Nai-Wen Guo
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/85836391227818524230

碩士 === 國立成功大學 === 行為醫學研究所 === 103 === Past researches indicate that patients who were treated with WBRT may have declined mental functions, such as memory, or executive function. But as for the attention disturbance is seldom studied in previous researches. This study investigates the mental function and attentional function of patient with brain metastases during the 2~3weeks WBRT, and the application of the neuropsychological assessment were discussed. 21 patients treated with WBRT and 22 normal controls were assessed Mini-Mental State Examination (MMSE), WAIS-III Digit Span, Comprehensive Non-verbal Attention Test Battery (CNAT) at different time-points: before WBRT (T0), after three to four days (T1), within a week after WBRT (T2). The results of the present study have revealed that, patients’ total score of MMSE were significantly lower than normal controls in T2. The patients’ total score of MMSE during the 2~3weeks WBRT were not significantly changed. As for attention, patient took longer to finish trials of selective attention in T2, but other attentional functions remains the same after WBRT. The correlation between MMSE and CNAT showed that patients have more correlation agreement difference in T2, suggests the different pattern of functional change during the WBRT. We suggest use the extra item of MMSE-“reading backwards” to predict the possible attentional function change.