| Summary: | 碩士 === 國立成功大學 === 護理學系 === 103 === Chemotherapy-induced peripheral neuropathy (CIPN) is one of the side effects caused by chemotherapy, and its symptoms are related with sensory or motor nerve injury, resulting in numbness, unsteady gait. This study aims to investigate the important impacting factors of peripheral neuropathy on falls in cancer patients receiving Taxanes, Vinca alkaloids and Platinum-based chemotherapy. It was the retrospectively case-control study, enrolling 163 hospitalized patients who had CIPN with and without falls between January 2009 and December 2013 in southern teaching hospital oncology ward. Using logistic regression model, the risk of falls were significantly associated with the more longer disease duration (odds ratio [OR] = 3.079; 95％ confidence interval [CI], 1.256~7.549, p = 0.014)、the severity of CIPN(OR = 0.008; 95％CI, 0.001~0.209, p＝0.004). Besides, the accumulating doses of oxaliplatin and cisplatin were significantly associated with the risk of falls（p＜0.05）。All the results may provide the information on reducing injurious falls of inpatients with CIPN in oncology ward and avoiding interruption of cancer treatment, thus it will ensure patient safety and improve the quality of care.
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