Monitoring and bioassay-directed fractionation of endocrine disrupting chemicals in Taiwanese rivers

• Main Authors: Po-HuiLin, 林柏輝
• Other Authors: Pei-Hsin Chou
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/22755430661037421168

碩士 === 國立成功大學 === 環境工程學系 === 103 === Pollutant emissions from human activities, which contain (anti-)estrogenic and (anti-)androgenic endocrine disrupting chemicals (EDCs) are discharged into rivers. EDCs have the ability to combine with the hormone receptors and interfere the endocrine system of organisms. To evaluate the concentrations of EDCs in the water and suspended solids (SS) of Taiwanese rivers, yeast-based bioassays, high performance liquid chromatography (HPLC) and liquid chromatography tandem mass spectrometry (LC-MS/MS) were used to detect EDCs in water and SS phase samples. The results of bioassays showed that (anti-)estrogenic activities were detected in some samples, and anti-androgenic activities were detected in a few samples. According to the results of chemical analysis, natural estrogens like estrone, and synthetic compounds, such as bisphenol A, chlorinated bisphenol A and nonylphenol were widely detected in most of the water phase samples by LC-MS/MS. The relationship between estrogenic and anti-androgenic equivalent concentrations of bioassays and LC-MS/MS demonstrated that natural estrogens were major contributors for estrogenic activities in river samples, and combined effects of EDCs might play an important role on the evaluation of estrogenic and anti-androgenic activities.