One-Pot Synthesis of L-DOPA Imprinted Nanoparticles with Fluorescent Functionality for Controlled Release and Sensing Similar Molecules

• Main Authors: Chang-LongKao, 高彰隆
• Other Authors: Chun-Hsiung Kuei
• Format: Others
• Language: en_US
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/82197460702930836284

博士 === 國立成功大學 === 化學系 === 103 === The major goal of this dissertation is develop fluorescence resonance energy transfer tag and biomimetic materials for molecular recognition. The molecular recognition platform is based on molecular imprinting technology, micro-processes and nanotechnology, which can be applied to lead molecules, proteins and biological specimens screening, bio-imaging, on-line concentration, qualitatively and quantitatively analytical methods. The major study will be to synthesize fluorescent tag and modify all functionalized molecular imprinting materials to biocompatible materials. Those biocompatible materials are molecular probes and can friendly bind with lead molecules, proteins and biological specimens. Qualitative and quantitative analysis will be evaluated by ultraviolet-visible spectrometer, fluorescence spectrometer, flow cytometer, gas and liquid chromatography coupled with mass spectrometer. The fluorescence resonance energy transfer tag will assist the sensing system for high throughput screening by integrating our methodologies with combinatorial chemistry in the future. All development in this project is to expand its potential in analytical chemistry.