Poly(acrylic acid)-Poly(2-ethyl-2-oxazoline) Interpolymer Complexes:Interaction with Sodium Dodecyl Sulfate and Application in Drug Carrier

• Main Authors: Wei-ChihCheng, 鄭偉志
• Other Authors: Sheng-Shu Hou
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/96360577505091005675

碩士 === 國立成功大學 === 化學工程學系 === 103 === In this study, polymer concentration and the pH of polymer solution was shown to have significant effect on the interaction between poly(acrylic acid) (PAA) and poly(2-ethyl-2-ozazoline) (PEtOz) and also on the structure of the interpolymer complexes (IPCs). In addition, Sodium dodecyl sulfate (SDS) was introduced into PAA/PEtOz solution so as to mimic the the microstructure change of interpolymer complexes caused by amphipiles in biological system. The competitive behavior between IPCs and SDS were studied in terms of pyrene solubilization and transparency. The microstructure of PAA-PEtOz IPCs was found to be varied with the amount of SDS added. Futhermore, doxorubicin (DOX) was added to PAA/PEtOz solution in order to examine the drug-loading capacity of PAA-PEtOz IPCs. It was found that the hydrophobicity of PAA-PEtOz IPCs dominated the loading efficiency of DOX before IPCs forming precipitate due to the growth of size by the solubiliztion of DOX. Moreover, the release rate of DOX from PAA-PEtOz IPCs was also found to be depended on the hydrophobicity of IPCs.