Thermo-Responsive Supramolecular Hydrogels Formed by Cyclodextrin and Peptide Amphiphiles
碩士 === 國立成功大學 === 化學工程學系 === 103 === In this study, we reported the preparation of thermo-responsive supramolecular hydrogels via inclusion complexation between cyclodextrins (CDs) and peptide amphiphiles (PAs). Alkylamine were used as the macroinitiator of ring-opening polymerization (ROP) to synth...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2015
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| Online Access: | http://ndltd.ncl.edu.tw/handle/44885431376661223600 |
| Summary: | 碩士 === 國立成功大學 === 化學工程學系 === 103 === In this study, we reported the preparation of thermo-responsive supramolecular hydrogels via inclusion complexation between cyclodextrins (CDs) and peptide amphiphiles (PAs). Alkylamine were used as the macroinitiator of ring-opening polymerization (ROP) to synthesize PAs. CDs threaded onto alkyl chain and form inclusion complex. The network structure of hydrogels was composed of hydrophobic interactions between alkyl chain and inner cavity of CDs, hydrogen bonding between CDs and side chain of PAs. The gel-sol transition temperature and gelation concentration were tuned by alkyl chain length, type of amino acids and CDs, the molar ratio of CDs and PAs. The secondary structure of peptides was mainly random coil. C12Thr20+α-CD hydrogels formed lamellar packing and the one bilayer thickness decreased with increasing temperature. The intelligent hydrogels could be promising in tissue engineering.
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