Synthetic Studies toward the (-)-Oseltamivir based on Diels-Alder Reaction

Synthetic Studies toward the (-)-Oseltamivir based on Diels-Alder Reaction

碩士 === 國立中興大學 === 化學系所 === 103 === Herein, we wish to propose a concise synthetic strategy towards Oseltamivir. The synthesis relies on Diels-Alder (DA) reaction and our lab aziridination protocol. Preparation of diene 62 through Wittig reaction and preparation of dienophile 63 from ethyl acrylate 1...

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Main Authors: Chen-Ya Hung, 洪禎雅
Other Authors: Tu-Hsin Yan
Format: Others
Language:zh-TW
Published: 2015
Online Access:http://ndltd.ncl.edu.tw/handle/55216823944440748636
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spelling ndltd-TW-103NCHU50650202016-08-15T04:17:49Z http://ndltd.ncl.edu.tw/handle/55216823944440748636 Synthetic Studies toward the (-)-Oseltamivir based on Diels-Alder Reaction 探索以Diels-Alder反應得到(-)-Oseltamivir之路徑 Chen-Ya Hung 洪禎雅 碩士 國立中興大學 化學系所 103 Herein, we wish to propose a concise synthetic strategy towards Oseltamivir. The synthesis relies on Diels-Alder (DA) reaction and our lab aziridination protocol. Preparation of diene 62 through Wittig reaction and preparation of dienophile 63 from ethyl acrylate 19 was accomplished as envisioned. We generated molecular dissymmetry; by using (S)-proline-derived catalyst 98 derived chiral ligand in DA reaction. Aziridination of olefin and further fictionalization towards the completion of Oseltamivir is under progress. Tu-Hsin Yan 楊圖信 2015 學位論文 ; thesis 115 zh-TW
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description 碩士 === 國立中興大學 === 化學系所 === 103 === Herein, we wish to propose a concise synthetic strategy towards Oseltamivir. The synthesis relies on Diels-Alder (DA) reaction and our lab aziridination protocol. Preparation of diene 62 through Wittig reaction and preparation of dienophile 63 from ethyl acrylate 19 was accomplished as envisioned. We generated molecular dissymmetry; by using (S)-proline-derived catalyst 98 derived chiral ligand in DA reaction. Aziridination of olefin and further fictionalization towards the completion of Oseltamivir is under progress.
author2 Tu-Hsin Yan
author_facet Tu-Hsin Yan
Chen-Ya Hung
洪禎雅
author Chen-Ya Hung
洪禎雅
spellingShingle Chen-Ya Hung
洪禎雅
Synthetic Studies toward the (-)-Oseltamivir based on Diels-Alder Reaction
author_sort Chen-Ya Hung
title Synthetic Studies toward the (-)-Oseltamivir based on Diels-Alder Reaction
title_short Synthetic Studies toward the (-)-Oseltamivir based on Diels-Alder Reaction
title_full Synthetic Studies toward the (-)-Oseltamivir based on Diels-Alder Reaction
title_fullStr Synthetic Studies toward the (-)-Oseltamivir based on Diels-Alder Reaction
title_full_unstemmed Synthetic Studies toward the (-)-Oseltamivir based on Diels-Alder Reaction
title_sort synthetic studies toward the (-)-oseltamivir based on diels-alder reaction
publishDate 2015
url http://ndltd.ncl.edu.tw/handle/55216823944440748636
work_keys_str_mv AT chenyahung syntheticstudiestowardtheoseltamivirbasedondielsalderreaction
AT hóngzhēnyǎ syntheticstudiestowardtheoseltamivirbasedondielsalderreaction
AT chenyahung tànsuǒyǐdielsalderfǎnyīngdédàooseltamivirzhīlùjìng
AT hóngzhēnyǎ tànsuǒyǐdielsalderfǎnyīngdédàooseltamivirzhīlùjìng
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