Synthesis and Reactivity Study of the Tris[3-2-pyridyl)pyrazolyl]hydroborate Iron Complexes

• Main Authors: Kun-Yu Li, 李坤育
• Other Authors: Sodio C. N. Hsu
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/4ywxbq

碩士 === 高雄醫學大學 === 醫藥暨應用化學系碩士班 === 103 === Trispyrazolylborate (Tp&;#8722;) type compound is a very important ligand set for small molecules activation the metalloenzyme mimicking system. Tris[3-(2-pyridyl)pyrazolyl]-hydroborate (Tp(py)&;#8722;) is a new type of Tp- ligand set which provides additional pyridine coordination site in 3-postion to explore some new coordination behavior for metal complexes. It is worth mentioning that there are no example of iron complexes containing Tp(py)&;#8722; ligand. Therefore, we focus on the synthesis and reactivity study of Tp(py)FeCl compound for the outer pyridine arm may mimic the amino acid residue around metalloenzyme active center. The Tp(py)FeCl complex represents as the first example of iron complex containing Tp(py)&;#8722; ligand and the dangling pyridine arm can be used to mimic the second sphere coordination environment of the iron containing enzyme active site. The coordinated chloride ligand were replaced by N3&;#8722; and CN&;#8722; in DMF solution to give Tp(py)FeN3 (1) and Tp(py)FeCN (2) respectively. The structure of complex 1 was characterized by X-ray crystallography showing a five-coordination Fe(II) center similar to that of Tp(py)FeCl. Complexes 1 and 2 were all examined by UV-vis and Infrared spectroscopies. Complex 2 also can be characterized by NMR spectroscopy to confirm the low spin electron configuration and diamagnetism.