A TfOH Catalyzed One-pot Synthesis of Aryl-Substituted Benzoquinones and Quinones via C-C Bond Formation

碩士 === 高雄醫學大學 === 醫藥暨應用化學系碩士班 === 103 === 。Substituted naphthoquinone and benzoquinone derivatives exist widely in nature and exhibit various important biological activities including antibiotic, antitumor, antidiabetic and inhibition of HIV-1 reverse transcriptase. Among these, the aryl substituted...

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Main Authors:	Jia-Heng Jiang, 蔣佳恆
Other Authors:	Jeh-Jeng Wang
Format:	Others
Language:	zh-TW
Published:	2015
Online Access:	http://ndltd.ncl.edu.tw/handle/13452699380160562759

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spelling	ndltd-TW-103KMC055370052016-08-15T04:17:23Z http://ndltd.ncl.edu.tw/handle/13452699380160562759 A TfOH Catalyzed One-pot Synthesis of Aryl-Substituted Benzoquinones and Quinones via C-C Bond Formation 藉由三氟甲磺酸催化與一鍋化進行&;#37260;類與苯胺類的碳-碳鍵合成 Jia-Heng Jiang 蔣佳恆碩士高雄醫學大學醫藥暨應用化學系碩士班 103 。Substituted naphthoquinone and benzoquinone derivatives exist widely in nature and exhibit various important biological activities including antibiotic, antitumor, antidiabetic and inhibition of HIV-1 reverse transcriptase. Among these, the aryl substituted derivatives are of particular interest due to their presence in many natural products, such as belmacandaquinones and building blocks for many pharmaceuticals, natural products and dyes. By considering the importance of these aryl substituted benzoquinones and quinones, an acid catalyzed sequential one-pot approach was developed. This synthetic approach consists of oxidation of napthols/phenols to napthoquinone/benzoquinones followed by TfOH catalyzed arylation with electron rich arenes via C-C bond formation. Jeh-Jeng Wang 王志鉦 2015 學位論文 ; thesis 123 zh-TW
collection	NDLTD
language	zh-TW
format	Others
sources	NDLTD
description	碩士 === 高雄醫學大學 === 醫藥暨應用化學系碩士班 === 103 === 。Substituted naphthoquinone and benzoquinone derivatives exist widely in nature and exhibit various important biological activities including antibiotic, antitumor, antidiabetic and inhibition of HIV-1 reverse transcriptase. Among these, the aryl substituted derivatives are of particular interest due to their presence in many natural products, such as belmacandaquinones and building blocks for many pharmaceuticals, natural products and dyes. By considering the importance of these aryl substituted benzoquinones and quinones, an acid catalyzed sequential one-pot approach was developed. This synthetic approach consists of oxidation of napthols/phenols to napthoquinone/benzoquinones followed by TfOH catalyzed arylation with electron rich arenes via C-C bond formation.
author2	Jeh-Jeng Wang
author_facet	Jeh-Jeng Wang Jia-Heng Jiang 蔣佳恆
author	Jia-Heng Jiang 蔣佳恆
spellingShingle	Jia-Heng Jiang 蔣佳恆 A TfOH Catalyzed One-pot Synthesis of Aryl-Substituted Benzoquinones and Quinones via C-C Bond Formation
author_sort	Jia-Heng Jiang
title	A TfOH Catalyzed One-pot Synthesis of Aryl-Substituted Benzoquinones and Quinones via C-C Bond Formation
title_short	A TfOH Catalyzed One-pot Synthesis of Aryl-Substituted Benzoquinones and Quinones via C-C Bond Formation
title_full	A TfOH Catalyzed One-pot Synthesis of Aryl-Substituted Benzoquinones and Quinones via C-C Bond Formation
title_fullStr	A TfOH Catalyzed One-pot Synthesis of Aryl-Substituted Benzoquinones and Quinones via C-C Bond Formation
title_full_unstemmed	A TfOH Catalyzed One-pot Synthesis of Aryl-Substituted Benzoquinones and Quinones via C-C Bond Formation
title_sort	tfoh catalyzed one-pot synthesis of aryl-substituted benzoquinones and quinones via c-c bond formation
publishDate	2015
url	http://ndltd.ncl.edu.tw/handle/13452699380160562759
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A TfOH Catalyzed One-pot Synthesis of Aryl-Substituted Benzoquinones and Quinones via C-C Bond Formation

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