| Summary: | 碩士 === 高雄醫學大學 === 醫藥暨應用化學系碩士班 === 103 === 。Substituted naphthoquinone and benzoquinone derivatives exist widely in nature and exhibit various important biological activities including antibiotic, antitumor, antidiabetic and inhibition of HIV-1 reverse transcriptase. Among these, the aryl substituted derivatives are of particular interest due to their presence in many natural products, such as belmacandaquinones and building blocks for many pharmaceuticals, natural products and dyes.
By considering the importance of these aryl substituted benzoquinones and quinones, an acid catalyzed sequential one-pot approach was developed. This synthetic approach consists of oxidation of napthols/phenols to napthoquinone/benzoquinones followed by TfOH catalyzed arylation with electron rich arenes via C-C bond formation.
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