The association between dietary markers and renal function indicators in type 2 diabetic patients

• Main Authors: Yen-Ling Liao, 廖彥菱
• Other Authors: Meng-Chuan(Michelle) Huang
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/ayw48h

碩士 === 高雄醫學大學 === 醫學研究所碩士班 === 103 === Background and aims. Diabetic nephropathy is common complications of diabetes, and has contributed to increased medical resources and costs. Few studies have explored relations between dietary patterns risks of diabetic complications such as diabetic nephropathy.. The purpose of this study is firstly (1) to investigate correlations between dietary patterns (dietary factor scores) and biomarkers (folate, ferritin and n-3 Long Chain Polyunsaturated Fatty acids (n-3 LCPUFA), secondly (2) to examine associations between these dietary biomarkers and renal function indicators in 760 patients with type 2 diabetes in a cross-sectional study. Methods &; Materials.Diabetic patients (n =760) were selected from a cohort participating in a diabetic control study Diabetes Management through Integrated Delivery System (DMIDS) in Taiwan during year of 2008-2009. Food-frequency questionnaires obtained during two consecutive years of 2008-2009 were used and three dietary patterns (fatty meat, vegetable and fish and traditional Chinese snack), were generated using factor analysis. Plasma levels of ferritin, folate and erythrocyte n-3 LCPUFA were measured. Creatinine (Cr) and(estimated glomerular filtration rate (eGFR) were used as renal function indicators. Result. Folate appeared to correlate positively with fish and vegetable dietary pattern scores, and negatively with and fatty meat pattern scores, respectively (p trend<0.001). Ferritin correlated significantly with fatty meat pattern scores only (p trend<0.001). n-3 LCPUFA was positively associated with fatty meat as well as vegetables/fish (p trend <0.001), but negatively with Chinese snacks (p trend <0.001). Our results suggest that eating patterns in part contributed to changes of blood dietary biomarkers. In univariate analysis, folate correlated significantly with lower Cr (p=0.038) concentrations and marginally with higher eGFR (p=0.054).In contrast, ferritin was associated with higher Cr (p=0.054) and lower eGFR (p=0.129) at marginal significance。LCPUFA as well as DHA did not appear to be associated with any of renal function indicators. Upon adjustment for confounding factors, folate correlated significantly with lower Cr (p=0.038) and marginally with higher eGFR level (p=0.054). In contrast, ferritin correlated with higher Cr (p=0.054) and lower eGFR (p=0.129) at marginal significance. LCPUFA as well as DHA did not correlated with renal function indicators. Conclusions. Frequent consumption of fish and vegetable and fatty meat may be reflected by changes of blood folate and ferritin. These two blood bio markers also appeared to correlate with better and worsening of renal function indicators in type 2 diabetic patients. Prospective study is needed to explore association between dietary markers and renal function development in type 2 diabetic patients.