The risk of traumatic brain injury in patient with mood disorders－Taiwan''s National Health Insurance Research Database analysis

• Main Authors: Chen-Hsiang Su, 蘇振翔
• Other Authors: Cheng-Sheng Chen
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/h8nhpu

碩士 === 高雄醫學大學 === 醫學系神經學科碩士班 === 103 === Abstract Objective: Patients with mood disorders are at highly risk of traumatic brain injury. But the association between mood disorder and traumatic brain injury is unclear. The aim of this study was to examine the difference between the risk of traumatic brain injury in patients with major depressive disorder or bipolar disorder with different sex and age of onset. Methods: This study used the data of Longitudinal Health Insurance Database in 2010 from the National Health Insurance Research Database. We analyzed 2270 patients with major depressive disorder or bipolar disorder and 9080 controls with adjustment of covariates to investigate the difference of risk in occurring traumatic brain injury. Results: Participants with major depressive disorder or bipolar disorder were at higher risk and shorter onset time of TBI (P <0.0001), and the cumulative incidences of traumatic brain injury were zooming in the first few years after being diagnosed. Besides, middle-aged onset major depressive disorder or bipolar disorder (40~49 y/o) were at increased risk of TBI(adjusted HR of major depressive disorder : 3.30, 95% CI: 1.94-5.60; adjusted HR of bipolar disorder: 2.50, 95% CI: 1.37-4.57). Women with major depressive disorder has higher risk of TBI than men (adjusted HR in women: 3.25, 95% CI: 2.20-4.78; adjusted HR in men: 1.62, 95% CI: 1.09-2.40), and the similar results were observed in bipolar disorder (adjusted HR in women: 2.10, 95% CI: 1.36-3.22; adjusted HR in men: 1.50, 95% CI: 0.99-2.57). Conclusions: People with major depressive disorder or bipolar disorder were at increased risk and shorter onset time of TBI, especially in the first few years after being diagnosed. Besides, Women and middle-aged onset were at relatively high risk of TBI.