Study of Microfluidics Processed W/O/W Microspheres as Drug-Delivery Agents in Hydroxyapatite Bone Cement

• Main Author: 李其恩
• Other Authors: 駱榮富
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/19301112626544459948

碩士 === 逢甲大學 === 生醫資訊暨生醫工程碩士學程 === 103 === This study focuses on developing new medical material combining microspheres with dual drug release function and bone cement as customized orthopedic scaffold composites. Such proposed innovative orthopedic composites enables to offer patients a better medical treatment for perfecting bone repair and wound surgery. The microfluidic technique was employed to include both hydrophilic and lipophilic drugs to form a W/O/W gelatin/sodium alginate microspheres, which can cope with suppressing osteomyelitis more effectively. Microfluidics design and surface modification process for micro-channels to produce uniform microspheres containing different kind of drugs into core-shell structure. The design of gelatin/alginate composite microspheres with of dual drug release function combined with hydroxylapatite (HA) bone cement is attempted to emulate human skeletal structure in order to perform a slow-release drug efficacy.