| Summary: | 碩士 === 中原大學 === 化學工程研究所 === 103 === Metal materials are widely used in medical device or parts, and the most common were medical grade titanium and stainless steel. Although metals have good mechanical properties and processing properties but lack biocompatibility when applied to human body, such as the reinforcement or repair, usually occurring of the foreign body granuloma, caused injured again. This study focuses on the self-assembling zwitterionization via thermal-induced immobilization method for metal substrates to achieve the general biofouling control. We use the zwitterionic sulfobetaine monomer (SBMA) and glycidyl methacrylate monomer (GMA) to synthesize a set of triblock copolymers (pSBMAn-b-pGMAn-b-pSBMAn; n = 25, 50, 75, 100) with controlled block ratios of SBMA/GMA. The study also discussed the effect of copolymer grafting density on its antifouling capability. The outstanding antifouling performance of zwitterionic pSBMA brushes within stable chemisorption via covalent bounding can be achieved by epoxy groups of polyGMA reacted with hydroxyl groups on surface, which was determined by 1H NMR. The results showed that stainless steel surfaces anchored with pSBMA brushes provide good fouling resistance in plasma proteins, blood cells, tissue cells and general bacterial. The results also showed the modification method successfully applied to the antifouing coating on surgical stainless steel blade and titanium metal root for the control of bacterial resistance.
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