Study of Surface Modification on Zirconia for Enhancing Biocompatibility

• Main Authors: Yin, Shu-Han, 殷菽韓
• Other Authors: Wu, Shih-Ching
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/36782750968735240861

碩士 === 中臺科技大學 === 醫學工程暨材料研究所 === 103 === 　　Because of the aesthetic, biocompatibility, and excellent mechanical properties, zirconia becomes a potential material for dental implant. However, zirconia is a bio-inert material, that is, there is no chemical bonding between the bone tissue and the zirconia implant. This phenomenon restricts its application in the dental implant field. 　　In this study, the hydroxyl (OH) functional group is formed on the surface of sintered zirconia (3Y-TZP) specimens, using the chemical treatments of sodium hydroxide, acetic acid, or phosphate acid, to processing surface modification and enhancing the biocompatibility. Some of the specimens also immersed in the DOPA (3,4-dihydroxy-L-phenyl-alanine) solution and then grafted the OMPⅢ peptide, to improve the biological activity of zirconia. 　　Experimental results showed that the hydroxyl (OH) functional group is formed on the surface of sintered zirconia (3Y-TZP) specimens, using the chemical treatments of sodium hydroxide, acetic acid, or phosphate acid, to enhancing the biocompatibility. After immersed in the DOPA (3,4-dihydroxy-L-phenyl-alanine) solution, the zirconia specimens did show the better biocompatibility. It is obvious that the OH functional group is helpful for the coating of DOPA. The osteopontin-motif-peptide (OMPⅢ)-grafted zirconia did have better biological activity.