Biological monitoring of bisphenol A in umbilical cord blood and venous blood associated with dietary intake for pregnant women

• Main Authors: Jia-Yun Li, 李佳芸
• Other Authors: 毛義方
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/81358586013252040206

碩士 === 中山醫學大學 === 職業安全衛生學系碩士班 === 103 === Bisphenol A (BPA) is one of high production and demand chemical, it is mainly used as the manufacturing materials of epoxy resin , polycarbonate, and other plastics. Recent studies have found that BPA at low dose might cause the changes of cell function, brain development, reproduction, type-2 diabetes, cardiovascular disease and other health effects. There is a country of massively product and frequently use plastic articles, plastic food containers in Taiwan. For the study of the human blood is also lack in tihs country; furthermore, BPA might have hazards for pregnant women and offspring, therefore, the purpose of this study is to examine the relationship between BPA concentration in blood of pregnant women and their background and dietary factors, in order to understand the internal dose of pregnant women and the primary source of exposure to BPA. Study subjects were 30 and 105 pregnant women from the northern and the central of obstetrics and gynecology hospital in Taiwan. This study was conducted the biological monitoring of BPA in umbilical cord blood and venous blood from pregnant women, questionnaire, and analysis of BPA level in urine. The questionnaire included sociodemographic, dietary habits, medical circumstances, history of disease and others. BPA concentrations in plasma was detected by HPLC/Flourescence, the method detection limit was 0.48 ng/mL, the recovery was 96.9 ± 11.8%. This study results showed that BPA concentrations was detected in 27% and 51 % ,the mean was 2.7±13.0 ng/mL and 3.9±5.2 ng/mL in venous blood and umbilical cord blood of pregnant women, respectively. It indicated that the ability of the placenta might not to oppose BPA. The statistically significant correlation was found between blood and urine of BPA concentrations with pregnant women who drank milk, the average daily number of microwave foods using plastic wrap, and had eaten contraceptive drugs (p<0.05); More than 70% Heating and stored food in plastic containers, the average concentrations of BPA for pregnant women who had eaten contraceptive drugs were 5.3 times higher than not eaten. 　 This study found that pregnant women used plastic containers very popular in Taiwan, and no matter in blood or in urine also exposure to BPA; moreover, the concentrations of exposure BPA were higher than other countries.