| Summary: | 碩士 === 中山醫學大學 === 醫學研究所 === 103 === Objective: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, especially in the Asia pacific area. Liver transplantation is theoretically the best option because it cures HCC and the underlying liver disease. The overall survival rate at 5 years after liver transplantation was around 70-75%. In contrast, 5-year survival rates after liver resection were only 40% to 65%, and the 10-year survival rate was 29%. The high incidence of HCC recurrence following liver resection is a serious issue. The recurrent rate is as high as 50-60% at 3 years and 70-100% at 5 years. This high recurrent rate precludes long-term tumor-free survival of the patients with liver resection for HCC. Our study reviewed the treatment of liver cancer patients receiving liver resection and their recurrence experience to analyze the impact of the risk factors for recurrence.
Methods and Materials: This study enrolled the patients with early primary HCC who received liver resection in Medical University Hospital from June 2010 to February 2015. Retrospective study designs are applied. The data were evaluated with a logical formula regression analysis, and assess the risk factors that associated with recurrence followed by discussion.
Results: We recorded a total of 89 patients with a mean age of 61.6 years. Total of 28 cases relapse after surgery. There are hepatitis B patients with and without the use of anatomical liver resection in patients must be more closely tracked. The probability of cancer recurrence that with hepatitis B is 10.476 times compared with no hepatitis B (recurrence hazard ratio: 10.476 ; 95% confidence interval, 0.928 - 118.245); the probability of cancer recurrence that not using anatomical resection, is 3.072 times (recurrence hazard ratio: 3.072; 95% confidence interval, 1.018 - 9.268) compared with have anatomical resection.
Conclusion and Suggestion: According to our study, hepatitis B patients and patients without using anatomical liver resection must be more closely tracked; because of these two groups of patients have the higher probability of cancer relapse.
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