Apple polyphenol inhibits colon carcinoma metastasis via targeting snail binding to focal adhesion kinase

• Main Authors: Chia-Hung Hung, 洪嘉鴻
• Other Authors: 王朝鐘
• Format: Others
• Language: zh-TW
• Published: 2015
• Online Access: http://ndltd.ncl.edu.tw/handle/74137737251761409603

博士 === 中山醫學大學 === 生化暨生物科技研究所 === 103 === Apple polyphenon (AP) has been reported to possess potent anti-tumor activity on several carcinomas, but the effects of AP on colon cacner with emphasis on metastatic capability is not clarified. Herein, we aimed to investigate inhibitory effects of AP on colon cancer cells. Our results revealed that AP treatments insignificantly affected cell viability, proliferation and cell cycle distribution of colon cancer cells DLD-1 but suppressed migration, invasion, colony formation and adhesion of the cell. In addition, AP reduced expression of cytoskeletal protein tubulin and F-actin, and consequently altered the cytoskeleton structure. Interestingly, we found that AP treatments reduced expression of focal adhesion kinase (FAK) but not Talin,